Need a nudge with the “Anticipating woes …” clue please
Otherwise have a full grid and have worked out the larger than life characters. Struggling to work out how to get 42 cells though, unless there is one exception to the 180degree symmetry affecting the starting cell for “US disorders …”
No luck yet with the synonyms, but PDM can’t be far off.
I think preamble would have been clearer if the “and” in the second sentence read “that”.
Enjoyed the puzzle so far, but think it must be the toughest this year