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Spot on jazzlover, ask² is a newt,
Nor(i) in ( a + a(s)k); is = 's
I suppose it could also be
Or(e) in (an + a(s)k)

Thanks so much both of you. I'll grind on with this. (Found this week's Listener much more fun).

35a Brief reminder to inject hormone shot, - I have ?OE?O?E have I gone wrong?
I'm very behind with top left corner, any tips for 2d or 13a welcome!

It's epo (hormone) in toke(n).

This was definitely a slog but with just enough of a promise of a reveal and pdm and as others have said, a very neat grid construction. Not as good as Ifor's recent primal offer a couple of weeks ago but still v.good.

2d is a metal but not one you'd find in Bradford. The instrument is a tabla.

13a - whole = sum and front = brass. Now get rid of all the "suns".

This was a clever idea for a puzzle and very well implemented in the grid but it was spoilt but some weird clues.