I am trying the safe strategy of using 10 different letters in the first 2 guesses with 3 vowels in the first word and the other 2 in the 2nd if possible.
I go with the Scrabble best practice of using letters from RETAINS (best 7 letters to have on your rack in Scrabble) in the first word, so I am using RAISE for my first guess atm.
Not using 10 different letters means you are more likely to get it in 3 tries though whereas using 10 different letters in first 2 guesses means you are more likely to get it in 4 or 5 I think.