manic mary - two fairly straightforward anagrams got me started (6dn and the one at 2dn which surrounds REV). Both are normally defined.
The hard part is moving the definitions around because they're often more than one word (and they're sometimes very obscure).
The fact that an across entry might have more than one instance of the same 'lost letter' complicates matters too. And some lost letter clues have also had their definitions 'exiled', so it can be hard matching things up.
The literary work is pretty obvious, as is the unclued 15dn.