Dylan,
In 12dn, "Following endless problems, I have to take drug for distress" (8), the definition is "distress" as a verb. The first four letters of the answer are the first four letters of a five-letter slang word defined by Chambers as "aggressive behaviour or trouble-making, esp. between gangs, racial groups, etc.; problems or difficulties". The other four letters of the answer are the standard contraction of "I have", into which a one-letter abbreviation for a drug is inserted. The first three letters of the answer to 12dn are the same as the first three letters of the answer to 3dn.