There are three that I am not sure about, so any clue or help would be appeciated;
16d. Like a strict TT, stony, son-of-a-bitch, eastern Republican (4.5).
I have C?L?S???R.
COLD SOBER occurs to me as a possible answer, as in stone cold sober. as son of a bitch can be abbreviated to SOB, but I don't entirely follow this clue.
26a. Screwed on entering appropriate place? (5)
I have ??N?D. If the appropriate place is BED, ON entering becomes BONED if my answer to 16d is correct, a slang expression I am not familiar with but I believe it can mean Screwed in the sense of broken, or ruined. Am I right?