dxx, I don't consider myself to be in any position to know whether this was the best puzzle all year, having only even looked at a handful; likewise, although I took a few years off, I confess I'm not sure quite why people are saying that this is the best puzzle in decades as long as Bandmaster's Duet For One exists.
Still, I enjoyed it. Cluing was fair, which was a useful hook to even bother trying; I guess as a scientist the theme of using AGCT coding appeals to me; and I suppose first getting into Listeners at all via the numericals explains why something that echoes those sorts of puzzle would appeal to me.
I'm sure what a "flawless" puzzle would even look like, but presumably at least one requirement is universal acclaim, so by that standard this one has fallen short. I stand by my suggestion, whether it's biased by hindsight or not, that this was accessible with less cold-solving than many feared, though. It is, after all, hard to tell how much you need for a logical solve when you don't even let yourself try. I spent the first period too intimidated by the journey to even start, but once I did I was surprised how much progress could be made using the information given and without always needing the checking answers.
Really, all I'm saying is that (a) I enjoyed it immensely, and (b) I'd encourage others to persevere.