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Threw huge dart for child? (8)

Miss the drugs? No end in sight, a bummer ! (8)

She motioned for drug cheat's execution (8)

...involved rough trade, or missing child (8)

With a change of leader laughter becomes her (8)

All girls hate drugs being cut without the foremost substances (8)

Edit...
All girls hate drugs being cut without the foremost of substances (8)

Issue experimental heart drug with no reservations at first (8)

Butcher decapitated twice after Germany issue (8)

D(sl)AUGHTER
Terry Butcher was the captain of England when England played Germany in the Italia 90 World Cup (a semi-final defeat on penalties) the one where Gazza cried 😢

Doctor, showing zero or little emotion, announces, 'it's a girl' (8)