Thank you for answers.
You know it's time to throw in the towel when you've got every crossing letters to a word but still can't get the answer. Not surprising really, when I put them into a word finder site and got words I've never heard of - orpin, octillion, solidi, propjet, flypitchers.
Time to give up but could you put me out of my misery with one more.
8d Trouble-making sextet (4-1-5)
How is 'half-a-dozen' (assuming that's the answer) trouble-making?