Given the constraint of the 25 partitioned primes possessing 49 digits and summing to twice 16ac, there are not that many possible answers for 1a. 7d shares a digit with its square root and as it forms the final column of the grid can itself only contain the digits 1,2,3,5,7 or 9 thereby considerably reducing the possible answers. It's then a matter of checking that 4d isn't prime and everything soon falls into place.