Hi Julia
I hope this helps.
The two clues that are synonyms are 14 across and 21 across.
the applied instruction is Good-for-Nothing
or in the case of this quiz G for O, therefore the clues that clash should have a G substituted for the O.
So, looking at 1 across Orange is the solution to the clue.
1 down, Gut is the solution. Following the instructions 1 across must be entered as Grange, which is still a normal word.
wombat