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Why 49ers movement had an element of euphoria (4,4)

49ers run the ball for gain (4,4)

American football.
San Francisco 49ers (aka 49ers) - prospectors
To run the ball is to rush to gain yardage.

Proceed with lethal dosage to get high through vein (4,4)

Clementine’s father gave his old shoulder a shrug during this boom time (4,4)

Once upon a time run on nuggets (4,4)

Yellow fever? (4,4)

Peter Lalor gave his old shoulder a shrug and built the Eureka Stockade (4,4)

He went from digging rotten potatoes to digging gold (the Stockade was 180 yrs ago today) - the birth of Australian democracy [when democracy was populist].

Heavy metal band's signing bonus (4,4)

Gold Rush
Canadian band 'Rush', whose genres included heavy metal.

Signing bonus - gravy/bonanza/windfall etc.

Proceed with lethal dosage, get high through vein? (4,4)

Listening to Spandau Ballet can cause euphoria in California (4.4)