I must be very dim today. I have a filled grid, the location and have filled the bottom row (assisted by the 8 letters). No problemo, I thought. But "career"?  Wiki reminds me of the story, in which the 6-letter guy doesn't do much apart from the last thing he does.  I can find no 6-letter steps along the way.  I imagine the replacing symbol is important, but that doesn't shed any light (sorry).  I need a nudge.