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Any hints please!

5d Man, perhaps, to dissolve regularly (4)
?S?E

17d Deer receiving setback from TV actor (3,4)
?O? L?W?

5d. ISLE (of Man)
Regular (alternate) letters of 'dIsSoLvE'
17d. ROB LOWE
BLOW, setback, in ROE, deer.

Thank you mattrom! Wish I was clever!
I was fixated with 'DOE' being the deer. Might have helped if I had heard of Rob Lowe! I have now - perhaps he will come up in a crossword again!