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One solution unparsed -

With this cream, spot’s about to vanish (6) L?T?O?

It’s almost certainly lotion, and almost certainly something obvious, but I just can’t see it.

LOCATION (spot) with CA vanishing

Thanks, Buddy.
What a great clue, but so annoying that I just couldn’t see it after a monumental two-hour battle to solve and explain the rest of the puzzle. My powers are waning :-)