An enjoyable Jumbo, but just wondering about these?
3 Down - "Caretaker trimmed edge of grass" (5) I-R-E
(I can only see IMRIE, as in Celia)
4 Down - "Covered in panels, cart sped along, spilling nothing"
(10) S-I-S-O-E-
48 Down - "Mission that has infiltrated site of nuclear bomb
development?" (5) A-A-O (Alamo?)
46 Down -"Wicked stinging plant about to fell daughter" (7)
T-I-F-C (I presume this is TRIFFIC?)