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Answers have a silent letter in them
1)College sounds tearful (8)
2)Inflammation of the lung consequent upon Maine resort (9)
3)Western Region reorders steel in struggle (7)
4)Kitchen appliance, say, in Northamptonshire (9)

2) is PNEUMONIA. An anagram of 'upon Maine'.
3) is WRESTLE. 'WR' followed by an anagram of 'steel'.
4) is a bit tenuous, but I would go for KETTERING.

Still thinking about 1).

4) is TOWCESTER. It is pronouced as 'TOASTER'.

Thanks again John

I think no.1 may be MAGDALENE (college) as it sounds like 'maudlin'.

1) is MAGDALEN (Oxford). It is pronounced as 'MAUDLIN'.

1 is MAGDALEN pronouced MAUDLIN

Oh sorry, MAGDALENE is too many letters.

Thanks John and Jerry for those