I'm glad to have seen this post as I was baffled by 2D as well, so thanks to all those involved.
This leaves me with one :
46D - Painful sensation when carrying six flags (6)
?A?V?G
I assume the 3rd letter is V giving, presumably, ?AVING but I can't parse any of the likely answers.
I'm almost certainly being thick, but would be grateful for any assistance.