Some strange clues in this one! In particular:
1Ac Issue making tense conservative laugh. (6)
_ C _ E _ M
Would appear to be SCREAM, but apart from being a laugh I don't understand the rest of it.
10Ac What's up with voicing on Top Gear? (4)
H _ G _
Seems to be HIGH, which is up, but the rest...?
24Ac Bubbly sort has no front; jerk's ultimately lacking. (4)
_ S _ I
ASTI? But apart from being a 'bubbly', why?