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28a Bloomers in a letter by Pentagon - demise of Reagan? (13).
Rhododendrons?

12d Garment is big top put on by female medic? (4,5).
Is there such a thing as a tent dress? If so, still can’t see the female medic.

21a Artist’s abnormal craving’s like this (7).
Picasso fits but can’t see where
The abnormal craving comes into it.

Dr - ess

Pica is craving + ‘s + so

All correct, I think. But you won’t like the parsings.

Rho (letter) + DoD (Department of Defense, aka the Pentagon) + end Ron’s I.e. Ron’s end (Reagan’s demise)

I think a Dr-ess is meant to be a female doctor.

One meaning of pica in Chambers is an unnatural craving for food

Sorry, first one is end (demise) Ron’s (of Reagan), which is much better

Thank you.

You were right quisling, I wasn't a fan of those.

48a Earth for example from plot and from abroad needed by Tom or Barbara? (5,6)
Second word looks like 'planet'.

50a Stoker needing hot drink not saying thanks? (5,5)
c?a?n ?r?t?.

47d Lime maybe drunk mostly without a hint of lemon (6)
???a?i.

50. A guess... Chain Grate?Cha, tea + Ingrate, someone who wouldn't say thanks.

48.Major Planet

Alkali ?

Lime is alkali
A L(emon) +Kali(ed) drunk mostly