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Clue: 49 across
"Inflammation given by which end of shoe?" (4)

Apologies for lateness of this query. The only reasonable solution I can come up with is "sore", but can't for the life of me see why. Help.

S or E, with S and E being (each) end of Shoe?

Hi, many thanks for that. Was completely flummoxed by that.

Thanks, Shuggie. It's a slightly odd clue, but reasonable, S Or E, which end of shoe...