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21a Ace dicky spooge in tube some way beyond rectum.
C?e?e? Sure that the c is correct and fairly confident with the two e's. Ace dicky suggests anagram of ace but can't get any further.

Caecum

First time I’ve ever seen “spooge” in a crossword. 🤔

Appears in most Viz crosswords which is why posters usually put the PG bit in. There is worse!

I’d never heard of this publication. (I’m American if you hadn’t realized.)

No - -maybe the clue is in math rather than maths but didn't get the rest of it. http://viz.co.uk/ -they do subs to the USA I believe .