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You might need to give us a hint Prof :)

Yes, I've located Loius CK online and established that he has three sisters, but can't find any of their names.

That's why the "?". It's not really his sister, but the name could be? Definition is tree.

Not my turn.

Is it sycamore? I am assuming he is a stand-up comic that does these types of jokes.

Not sycamore. There is a street with this name in my neighborhood. There is also one near my parents' house, and I was visiting frequently a couple of years ago when my father was in hospice care. I kept seeing the name, and I thought up the clue then. That's not going to be a hint though, so I will just add that Louis CK's sister should have the same "last name."

Sorry too deep for me. Could be conessis but I would have no idea why,

I kept seeing a girl's name in the street signs.

Would (or wood) the tree be known in other countries?
I can only think of 'shaddock' but I know that's not it.

According to Wikipedia, it is native to Canada and the northern US.

I think it might be Tamara CK.