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Help ( yet again !) please ........ I am bemused by these two.

21d. Bad state of mind that's ok for a mushroom. (6) ?l?s?d
22d. Response? Eat up a cocktail with bad manners. (6) ?p?a?e

22d uptake anagram of eat up +coc(k) tail

21d closed?

21 Mushrooms like to be in closed (dark) spaces, it helps them grow. Closed minds, however, are not good...

Thank you stevie gee and malone ....... what would I do without you? Thanks again.

Itsme, glad we could help.

There's a famous, ancient joke about bosses treating their staff like mushrooms ' 'we keep them in the dark and feed them s***'.

lol