Let’s assume that P, Q and R are all different integers. If not, you can have trivial solutions such as P=Q=R=0, P=Q=R=2, and so on (zero is both an integer and a perfect square).
Tatters has identified what I think is the solution with different integers that represents the values of P, Q and R closest to zero. However, there is an infinite number of solutions. Any Pythagorean triplet {a, b, c}, where a, b and c are all positive integers, and a^2+b^2=c^2, generates a solution where b is even. The solution is
Q=(b^2)/2
R=-(b^2)/2
P=a^2+Q=c^2-Q
If a is even, the solution is:
Q=(a^2)/2
R=-(a^2)/2
P=b^2+Q=c^2-Q
In any Pythagorean triplet, at least one of a and b must be even. If both are even, a triplet generates two solutions. For example, the triplet{6, 8, 10} leads to the following solutions:
P=82, Q=18, R=-18
P=68, Q=32, R=-32.
Are there any solutions where all three of P, Q and R are positive and distinct?