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Stuck on about a third of the clues, including:

22a One sister of Beth in British university, small and elegant (5)
16d University type had to be send down after a drugs bust (8)
20d Merit of some Parisian bottle unopened (7)

20, Des (n)erve.

20d DES ERVE
French for 'of some', DES + (n)ERVE, bottle

Bijou

Graduate

Deserve

22, B i Jo u ?

Thanks. How does "bijou" parse - I don't get all that "one sister of Beth" stuff?
Also can't parse "Graduate". I see the anagram for the first five letters but where does "ate" come in?

"Jo" was Beth's sister in Little Women.

In Little Women there were four sisters, Jo, Beth, Meg, and Amy.
And they crop up in crossword puzzles from time to time.

Thanks, don't know anything about Little Women.

StrangelyBrown, I think the Ate comes from the 'had' in the clue, and that comes after (as the clue says) 'a drug' bust, anagrammed. We ate fish for tea, we had fish for tea, sort of thing.