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I am in the US and only started this in the afternoon--so I am way behind you, my fellow Brits. As usual with Paul, I am struggling.
Some hints on 5a, 13d, and 23d would perhaps get me moving again.

5a Disease is definition - outside is a nipper shortened.

13d Pairs of the named clues when spoken sound remotely like these.

thanks...but a way to go...

23d. 4 divided by 50 = 0.08