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7a bacterium causing tetanus and botulism (11) c?o????????
20a spiritual (5,3,5,7,)
3D Really annoying (nuisance) 10 c?n?o?????
45a prepare for a difficult situation (6,4,3,7)
45d chocolate flavoured biscuit (7) ??????u
11d insert or fix into body (7)

Any help please

Hi Pammy

20a swing low sweet chariot
45d bourbon
11d implant
45a batten down the hatches

Clostridium

3d confounded

Thank you all very much