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Struggling this week.
3d substance released by nerve fibres 16 letters
NEURO?R???M?T?E?
50a the state of being pre-eminent or supreme 13 letters
T?A?????D???E
35d judgement; acuteness 11 letters
????E???E?T
These might help with the rest!

Neurotransmitter

35 Discernment

50 Transcendence

Thanks all! Has helped a bit, but I'll be back!