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It's what we have come to expect from setter Paul!

Stuck on last two in SE corner:
25A. Girl having incarcerated heartless girl in the country, there's no escaping it? (9). S-P-R---E; I assume it is built from Sue and starts super?
22D sound blasted down (4). --- E
Help!

22 Blue - down/sad. It sounds like Blew/blasted.

Superglue?

Thanks, Rusty and Malone. Obvious when you explain it!

Sitting looking at 13,23 down and getting nowhere and feeling stupid. 'Chambers features a rewrite of profuse rot on county (4-6,4) I have ?O?R-?O?T?R ?E?? Help, please.

thanks,
Wordless

Anagram for "profuse rot" followed by an abbreviation for a county, with the whole being something found in a chamber.

I'm badly stick in the NE area. 12ac might help me get moving. Mend outstanding circuitous routes, assuming formerly straight. I have ?E?E?O??????.
And also help please with 6d: Unfortunately not always supporting hack --getting there! I have ?? ?? ??A? I'm surprised no one else reported any trouble in that section :-(

12 Heterosexual, straight?

12 Mend in a medical sense (4)
around anagram of Routes and
Formerly - (2)