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This one's really got me confused! I think either the puzzle maker or I (more likely) have made a mistake!

10ac: "Extreme anxiety" ?A?T?E?S

13ac: "Sully; narrow gorge" ?E?I?E (I thought 'defile' would fit for sully but not gorge. And 'ravine' for gorge but not sully (according to my dictionaries) and the a in ravine doesn't fit with the 2dn, which is 'ediface', hence the final e would go where the a goes in ravine.

19ac "criminal underworld" G?N?L?N? The g?n might be 'gun' but can't get the rest of it.

Thanks.

19 Gangland

sully and gorge both are DEFILE

distress?
gangland

de·file
verb /diˈfīl/ 
defiled, past participle; defiled, past tense; defiles, 3rd person singular present; defiling, present participle

Sully, mar, or spoil
- the land was defiled by a previous owner

Desecrate or profane (something sacred)
- the tomb had been defiled and looted

Violate the chastity of (a woman)

noun /diˈfīl/  /ˈdēˌfīl/ 
defiles, plural

A steep-sided, narrow gorge or passage (originally one requiring troops to march in single file)

tautness ?

Have never heard of 'ediface' - are you sure it isn't 'edifice' ?

Thanks everyone! Yes, I had misspelled 'edifice' and had not been able to find the definition of defile for narrow gorge. I must find some new dictionaries!!!!