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1. Open an eye![6] ??H???
2. Famous ship is short of freight.[4] ?R??
3. A vital point when it comes to a purchase. [7] ?????U?
4. Keyless lock.[5] ?R?S?
5.One bent on trying to destroy you.[4.5] ???? ???M?
6. What it means to a barman. [7] ???L?A?

2 Argo

4 Tress

6 Italian

It = Italian Vermouth

1 Unhook

hook and eye

3 Fulcrum

Thank you mamya.