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Hi Mags
53a is eminent

Still stuck on a few!

10D supposed aid to cognition(8,3) T?I?K???/??A

6D Irrefutable (12) ??A?S???????

50A. Make someone appear guilty (11)

10d thinking cap
6d unanswerable
50a incriminate

10 thinking cap

Many thanks as I had a mistake on 30A.

26A relating to the heart & blood vessels (14) ?A?D???A?C ????

27D. Seriously devoted to a particular activity (8)

41D. Relating to the windpipe (8) ???C?E??

26 cardiovascular
27d addicted
41d tracheal

Thank you both -eminent makes more sense. I`d misspelt 41d
26a cardiovascular
27d addicted
Tracheal (that`s where I put in `I` instead of `E`
Mags.

22D Electrical or electronic transmission of information (17) T?L?C?M?????A?IN

32D. Severe lack of proper food (12) ???M???I?I?N

I should be able to get these but I'm stuck!

22d begins with T so that should help. The other has the M wrong. ( It is N from "understatement)

Telecommunication
Malnutrition