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19ac, 'Indefatigable, but unable to drive across America', ?I?E?E?S. Why tireless?

13ac, ' Grandad ultimately hampered by grim internet protocol, suffering', H???S?I?;

2dn, 'Upholsterer's first to stuff stretched seat', L?U?G??.

19 'Tireless' as in 'without tires' would only work in American (language) as it'd be 'tyreless' in English.
13 Hardship
2 Lounger (u/upholsterer's first(letter) and 'longer'/stretched.

Thank you.