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51d: Do not put up with one's cheek for a start! (5) T?M?C. The M is from my ans to 55a, multiparous, which I can't parse fully, so help would be appreciated.

tonic & nulliparous

Tonic

Nulliparous

55 Across is NULLIPAROUS

Many is NUMEROUS, take ME out and replace with A PILL backwards gives NULLIPAROUS = not having borne a child

51 Down is TONIC - Not put up is TON with one (I) and C(heek) for a start gives the answer

Thanks everyone!