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Please, please can someone help me with these last 3 clues?
10 down (11 letters) - Serious actress
T ? A ? E ? I ? N ? E
34 down (11 letters) - American hospital theatre
worker - A ? E ? T ? E ? I ? T
41 down (8 letters) - lacking sensitivity in dealing with others - ? A ? T ? E ? S

Any help very gratefully received. Thank you.

10d tragedienne
34 anesthetist
4a tactless

Thank you so much jazzgirl - I'm so grateful for your help - much appreciated.

You're welcome :)