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I've just got this one left and I just can't think of the answer. Can someone help?

Try INSOMNIA!
Jerry

Many thanks, I wasn't sure if it was that or INSIGNIA. I can't see how either fits with the clue

Hi Paul,
If one suffers from insomnia (such as I do) it
means you can't get off to sleep.As the clue is
given,one cannot get off with it. I hope this clarifies it for you.
All the best,
J

Excellent, that makes sense, I just wasn't looking at it in the right way.

Many thanks for your prompt responses Jerry