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22d Surrender hypodermic in the end - where did it go? (4,2) ???E ?N I can only think of give in, but makes no sense with the clue!

cave in?

I've been wrestling with this one. As Paul says, cave in, is an option.

ve + in = vein (where does the hypodermic go) is a possible avenue to look at. This would leave GI or CA. ???

logic; c - a vein

A yes, Paul. c from the end of hypodermic (double use)

Thank you all!