Have or had some of the same question marks.
Hope I'm not stepping on anyone's toes, or giving too much away.
39D: first 3 letters, Latin for "of itself" though includes genders.
Last 4 in Chambers for "off", transitive verb. Add "er" for the perpetrator.
30D: anagram with a deletion, leading to what we've said about some of the clues!
34A: think Freud (** for that one)
40D: "abrasive" is a noun.
46A: anagram with a deletion, & a Google.
22A: composite, def. in Chambers.
For me:
14A: def ?
36A: angler ?
Les, hope all goes well.