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I'm really struggling with Orlando's effort. Could anyone give me a hint on 21 dn to open up the SW corner please:
Trophy taken by Labour leader and whips (6)
No letters of course!

The trophy is a cricket one.

Think cricket trophy?

Thanks guys!
I may be back for more help later.

Thanks to the hint I've made some progress, but now have ground to another halt. Perhaps a hint on 17ac might get me going again:
State capital, mostly Italian city (6)
?R?(N)??
(I'm not entirely sure about the "N")
Thanks in anticipation

Think capital of

Think capital of US state with last letter missing- clue its on east coast

US east coast state capital, almost

Thanks - I had to scroll down a list on Wikipedia to find it!

Thanks to your help I've now finished, but there are several that I don't fully undertsand (or may have got wrong!) Could anyone provide explanations, please?
13ac Pick a quiet moment - I have APPOINT
20dn Country in Central America, country in Asia, and one midway?
I have ROMANIA (I can see OMAN, but don't get the rest)
(I was also going to ask about 4ac, but I've just worked it out)