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I just couldn't get going at all today...

"More work, but no discomfort here" = utopia.
"Stock of DNA in Penge ruined before ladies return?" = gene pool. Penge, fine but how exactly is the OOL formed?
"It's perfect with any cosmetic in beauty salon" = absolute.
"People who do this are working normally at outset" = earn.

Many thanks.

The LOO part refers to a ladies' toilet

Sir Thomas More wrote the novel(work) Utopia

The last one, Pook, are working=ear, normally at outset=n (first letter), therefore get Earn

Anagram of beauty salon minus letters A.N.Y

Great stuff, thanks to you all.