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Last two are killing me:
16A 'Sort out what really matters' [3,4,10&5] I have g-t ---s-r-o-i-s -i-h- and 3D 'Ancient Indo-European'[5] for which I have e-y-- can anyone help please?

Might the second one be Aryan?

And the first on - this doesn't match the letter-number you've given but is it "get your priorities right"?

Get ones priorities right

Yes - I think so - many thanks TWM

or rather, "one's" as Barry suggested

Stupot. Twm is right. 16ac - the last word is the opposite of left. does that help?

Yes - nany thanks Barrycat et al

39 ac. Looked easy - but `mark` does not work with 22 down - which I`m sure is right ! Any ideas, please?

What's the clue?