Hmm, tough one this week, or brain strain!
25a from the beginning of time: ---m-r---l.
NOT immemorial
46a rule applied unfairly: -o----//---n-a-d
57a go beyond: --a---e-d
23d moving from subject to subject:
---c-r-i-c
41d advertising agent: p---i-i--
43d narrowing of a bodily passage:
---n-s--