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25a tube trains in grey at front of station
s?????e
Is it shuttle ? Why ?
45d third rate not considered failure
c?a?h
must be crash (failure)
why ?

Sorry, no idea! But wondering if this is a new setter, and he/she will be out of a job soon?
I always understood that if it's a good clue, when you get the answer, you know for sure it's right.
I'm not on anything, but it's a good idea. have an opened bottle of a good red downstairs. Cheers!

FRANCIS
25a-S-YRINGE-S=station anag of- in grey(trains)
45d-yes C(third rate) not considered (RASH)

25 down is SYRINGE (anagram)

Thanks to everybody for help.