Thanks terry. I did think of bottle meaning nerve but I have a crossing letter that I felt certain of and that ruled out an R for nerve:
When emperor Nero, meaning to disregard me,fiddled (4,5)
For this I have ANNO NEGRI and that gives me the second N for the bottle clue. Maybe it's wrong, though.
Here is another way of coming at it:
Important in breaking into sealant, cap removed (7).
Possibly starts with E:
e - I - - - T
Is it EMINENT? (That would give me a final E for the bottle clue) I don't get the working of the clue re sealant.