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7d The sole catlike creature in the house (11)

I think this is Plantagenet, but can't see why.

"Genet [cat]" is a catlike creature, "Planta" could be an anat. term for the sole (e.g. "plantar wart").

Thank you geeker, hadn’t heard of either bit of that answer.

48a Record increases, not much at first, lead to offers of savings (9)

Discounts?

disc (m)ounts

Thanks.

18a Unprofitable? This joint succeeded, for one. T - A - K - E - S

It must be 'thankless' and I can see the joint (ankle) and 'this' with the 'i' replaced by an 's', ('succeeded, for one'). What I cannot see is how the parsing places the joint inside the 'TH...SS'.

Any thoughts?

I think it means that you make TH (I) S , into TH (ANKLE S) S. So this with “ankle s for one”, ie replacing it

Thanks Quisling. That explains it!

I finished this puzzle some time ago except for 5 down. I just can't make any sense of the clue. I'm clearly missing something!

For old chemist, too bad not to have these days back.
4 letters I have B-O-
Any suggestions?