Below are possible answers for the crossword clue Sign of fatigue.
4 letter answer(s) to sign of fatigue
YAWN
an involuntary intake of breath through a wide open mouth; usually triggered by fatigue or boredom; "he could not suppress a yawn"; "the yawning in the audience told him it was time to stop"; "he apologized for his oscitancy"
be wide open; "the deep gaping canyon"
utter a yawn, as from lack of oxygen or when one is tired; "The child yawned during the long performance"
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