Below are possible answers for the crossword clue Do one's darnedest.
8 letter answer(s) to do one's darnedest
ENDEAVOR
a purposeful or industrious undertaking (especially one that requires effort or boldness); "he had doubts about the whole enterprise"
attempt by employing effort; "we endeavor to make our customers happy"
earnest and conscientious activity intended to do or accomplish something; "made an effort to cover all the reading material"; "wished him luck in his endeavor"; "she gave it a good try"
Other crossword clues with similar answers to 'Do one's darnedest'