Below are possible answers for the crossword clue Defile.
5 letter answer(s) to defile
SULLY
charge falsely or with malicious intent; attack the good name and reputation of someone; "The journalists have defamed me!" "The article in the paper sullied my reputation"
French statesman (1560-1641)
make dirty or spotty, as by exposure to air; also used metaphorically; "The silver was tarnished by the long exposure to the air"; "Her reputation was sullied after the affair with a married man"
place under suspicion or cast doubt upon; "sully someone's reputation"
United States painter (born in England) of portraits and historical scenes (1783-1872)
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